Sickle Cell Disease is an inherited disease. Since it takes two Sickle Cell genes to make a person have the disease, we know that this trait is recessive.
If two parents, each with one Sickle Cell gene and one normal gene, were crossed, they would have a 25% chance of their offspring having Sickle Cell disorder. This cross is shown in the Punnet square below.
Normal red blood cells turn sickle shaped because the Sickle Cell gene causes them to produce an abnormal hemoglobin (the protein in blood cells that carries oxygen to different parts of the body.
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